Drug intelligence / Profile preview

Beijing Normal Univ. FAP compound [99mTc]Tc-L1

Development stage
Unknown
Lead developer
Beijing Normal University
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Gamma Emitters → Radiopharmaceuticals
01

Overview

Beijing Normal Univ. FAP compound [99mTc]Tc-L1: sourced facts only. name: "A nanomolar Kd value for [99mTc]Tc-L1 indicates its significantly high target affinity for FAP." [PMID:36972467]; target: "A nanomolar Kd value for [99mTc]Tc-L1 indicates its significantly high target affinity for FAP." [PMID:36972467]; developer: "Key Laboratory of Radiopharmaceuticals of the Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China." [PMID:36972467]; modality: "Two stable hydrophilic 99mTc-labeled complexes ([99mTc]Tc-L1 and [99mTc]Tc-L2) were obtained." [PMID:36972467]; stage: "The biodistribution and microSPECT/CT images obtained for U87MG tumor mice show that [99mTc]Tc-L1 has high tumor uptake with specificity to FAP and high tumor-to-nontarget ratios." [PMID:36972467]

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